Histological changes in methotrexate hepatotoxicity after boron application and evaluation of serum thiol-disulfide balance

Aim: Methotrexate, a folic acid antagonist, is chemotherapeutic drug used in the treatment of various inflammatory diseases as well some cancer types.The purpose this study; It study effects boric against hepatotoxic side methotrexate.
 Materials and Methods: Male wistar albino rats were divided into five groups six animals each. The group 1 control group. Methotrexate was administered to 2 3. While 4 given first methotrexate then acid, 5 Results: Light microscopic examination revealed sinusoidal dilatation, hepatocyte degeneration, vascular congestion-thrombosis, infiltration livers treated with methotrexate. observed that protective effect more effective than its treatment. In methotrexate, level oxidative stress-related parameters such lipid hydroperoxide, MPO disulfide increased (p< 0.05), whereas antioxidant native thiol, total thiol catalase decreased 0.05).
 Conclusion: study, it determined therapeutic liver damage caused by Oxidative hepatotoxicity resulting from application disrupted balance shift favor oxidation.